TABLE 1

HTS of the Spectrum Collection small-molecule library for novel HNC cytotoxics

Eighteen compounds were identified with preferential toxicity against FaDu cells. Percentage of inhibition of FaDu cell viability induced by each compound is shown. Validity of the screen was corroborated by the identification of existing chemotherapeutic agents such as mitoxantrone, dactinomycin, and mechlorethamine.

Compound	Molecular Formula	Inhibition
		%
Mitoxantrone hydrochloride	C₂₂H₃₀Cl₂N₄O₆	100
Mitomycin C	C₁₅H₁₈N₄O₅	96
Mechlorethamine	C₅H₁₁Cl₂N	91
Antimycin A	C₂₈H₄₀N₂O₉	91
Deguelin	C₂₃H₂₂O₆	90
Camptothecin	C₂₀H₁₆N₂O₄	89
β-Dihydrorotenone	C₂₃H₂₄O₆	88
10-Hydroxycamptothecin	C₂₀H₁₆N₂O₅	87
Actinomycin D	C₆₂H₈₆N₁₂O₁₆	87
Dihydrorotenone	C₂₃H₂₄O₆	85
Aklavin hydrochloride	C₃₀H₃₆ClNO₁₀	82
Pyrromycin	C₃₀H₃₅NO₁₁	80
Teniposide	C₃₂H₃₂O₁₃S	76
Floxuridine	C₉H₁₁FN₂O₅	72
Cetrimonium bromide	C₁₉H₄₂BrN	71
Alexidine dihydrochloride	C₂₆H₅₇ClN₁₀	60
Benzethonium chloride	C₂₇H₄₂ClNO₂	57
Aminopterin	C₁₉H₂₀N₈O₅	51