Cytotoxicity measurements of the various racemate and pure enantiomers of the benzo[b]acronycine diacetates
Data are presented as mean ± S.D. with the number of independent experiments (performed in triplicate).
| Cell Line | IC50 | Ratio S27590/S27589 | IC50 | Ratio S70255/S70256 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S23906-1 | n | S27589-1 | n | S27590-1 | n | S29983-1 | n | S70255-1 | n | S70256-1 | n | |||
| μM | μM | μM | μM | μM | μM | |||||||||
| KB3-1 | 0.095 ± 0.017 | 6 | 0.115 ± 0.018 | 6 | 0.227 ± 0.076 | 9 | 2 | 0.132 ± 0.012 | 3 | 0.237 ± 0.028 | 3 | 0.093 ± 0.018 | 3 | 2.5 |
| HCT116 | 0.199 ± 0.022 | 7 | 0.174 ± 0.025 | 3 | 0.472 ± 0.081 | 3 | 2.7 | |||||||
| HT29 | 1.48 ± 0.12 | 10 | 1.21 ± 0.18 | 4 | 1.65 ± 0.32 | 4 | 1.4 | |||||||
| MDA-MB-468 | 0.033 ± 0.007 | 3 | 0.038 ± 0.009 | 3 | 0.117 ± 0.041 | 3 | 3.1 | |||||||
| NCI-H460 | 0.22 ± 0.03 | 3 | 0.28 ± 0.01 | 3 | 0.59 ± 0.067 | 3 | 2.1 | |||||||
| NCI-H69 | 0.047 ± 0.014 | 3 | 0.047 ± | 2 | 0.072 ± | 2 | 1.5 | |||||||