R | 5-HT2A | |||||||
---|---|---|---|---|---|---|---|---|
Human | Rat | |||||||
WT | Ser→Ala | WT | Ala→Ser | |||||
EC50 | Emax | EC50 | Emax | EC50 | Emax | EC50 | Emax | |
nM | % | nM | % | nM | % | nM | % | |
2565 ± 70 | 34 ± 1 | 76 ± 41 | 64 ± 8 | 24 ± 7 | 93 ± 1 | 1228 ± 532 | 75 ± 1 | |
>10,000 | 0 | 1087 ± 331 | 24 ± 5 | 256 ± 34 | 59 ± 3 | 6187 ± 2203 | 33 ± 9 | |
264 ± 27 | 72 ± 6 | 71 ± 38 | 64 ± 3 | 77 ± 12 | 77 ± 3 | 394 ± 4 | 89 ± 5 | |
3485 ± 161 | 13 ± 2 | 1085 ± 272 | 20 ± 4 | 383 ± 128 | 58 ± 3 | 2985 ± 711 | 28 ± 3 | |
>10,000 | 0 | 220 ± 59 | 27 ± 2 | 317 ± 88 | 50 ± 2 | 788 ± 134 | 35 ± 1 | |
>10,000 | 0 | 974 ± 122 | 31 ± 1 | 179 ± 59 | 59 ± 2 | >10,000 | 0 | |
2917 ± 265 | 34 ± 2 | 239 ± 50 | 59 ± 7 | 40 ± 7 | 44 ± 2 | 1801 ± 590 | 65 ± 10 | |
>10,000 | 0 | >10,000 | 0 | >10,000 | 0 | >10,000 | 0 | |
>10,000 | 0 | >10,000 | 0 | 5078 ± 1814 | 15 ± 5 | >10,000 | 0 | |
>10,000 | 0 | 758 ± 117 | 10 ± 4 | 396 ± 64 | 43 ± 2 | 6168 ± 2221 | 13 ± 2 | |
>10,000 | 0 | 909 ± 175 | 10 ± 1 | 531 ± 45 | 44 ± 3 | >10,000 | 0 | |
>10,000 | 0 | >10,000 | 0 | >10,000 | 0 | >10,000 | 0 |