Representative reports of ERK5-dependent effects on neuronal cells.
| Neuronal Cell Types | ERK5-Dependent Effects | References |
|---|---|---|
| Cortical neural progenitor cells | Cell fate determination (neuronal differentiation) | Liu et al., 2006 |
| DRG neurons | Retrograde transport-dependent cell survival | Watson et al., 2001;Pazyra-Murphy et al., 2009 |
| Cortical neurons | ERK5/MEF2-depedent survival | Liu et al., 2003; Wang et al., 2006 |
| MN9D cells (dopaminergic cells) | ERK5/MEF2-dependent survival | Cavanaugh et al., 2006 |
| Superior cervical ganglion neurons | ERK5/CREB, Akt -dependent survival | Finegan et al., 2009 |
| DRG and spinal dorsal horn | Inflammatory pain | Xiao et al., 2008 |
| PC12 cells | Neurite outgrowth TH stabilization | Obara et al., 2009 |
| In vivo | ||
| Xenopus laevis | Neuronal differentiation | Nishimoto et al., 2005, 2007 |
| Conditional KO in neurons | Normal neuronal development | Hayashi et al., 2004a |
TH, tyrosine hydroxylase.