TABLE 1

Summary of the ligand-directed signaling of CB₁

Ligand	G_i	G_o	G_s	G_q/11	References
Classic
HU-210	++	++	++	N.E.	Bonhaus et al., 1998; Glass and Northup, 1999; Lauckner et al.,2005
THC	+	+	+	N.E.
Nonclassic
CP 55,940	++^a	×	+	N.E.	Bonhaus et al., 1998; Glass and Northup, 1999; Lauckner et al.,2005;McIntosh et al., 2007; Georgieva et al., 2008
Eicosanoid
AEA	++^a	+	+	N.E.^b	Bonhaus et al., 1998; Glass and Northup, 1999; Mukhopadhyay et al.,2005;McIntosh et al., 2007
Aminoalkylindole
WIN	++	+	++	+	Bonhaus et al., 1998; Glass and Northup, 1999; Lauckner et al.,2005; Mukhopadhyay et al., 2005; McIntosh et al., 2007
Diarylpyrazole
SR 141716	−	×	−	N.E.^c	Abadji et al., 1999; Lauckner et al., 2005; Mukhopadhyay et al.,2005

+ agonist effect; −, inverse agonist effect; N.E., no agonist or inverse effect (compounds probably act as neutral antagonists); ×, has not been directly tested for G_o-specific coupling.
↵a Acts as full G_i agonist but has reduced affinity or efficacy to specific G_i subtypes.
↵b Data obtained with MAEA instead of AEA.
↵c SR 141716 acted as an antagonist to the G_q/11 pathway but was not tested as an inverse agonist.