Summary of heterodimer-directed CB1 signaling
| Heterodimer | Gi/o | Gs | References |
|---|---|---|---|
| CB1 | |||
| Expressed alone | ++ | ++ | Felder et al., 1995; Hudson and Kelly, 2008 |
| CB1/D2 | |||
| Activated D2 | ++ | +++ | Glass and Felder, 1997; Jarrahian et al., 2004; Kearn et al., 2005 |
| Basal D2 | ++ | ++ | |
| CB1/A2A | |||
| Activated A2A | ++ | N.D. | Carriba et al., 2007 |
| Basal A2A | − | N.D. | |
| CB1/μ-opioid | |||
| Activated μ-opioid | + | N.D. | Rios et al., 2006 |
| Basal μ-opioid | ++ | N.D. | |
| CB1/β2AR | |||
| Active or basal β2AR | +++ | + | Hudson and Kelly, 2008 |
+ CB1 in heterodimer signals through this pathway; −, CB1 in heterodimer does not signal through this pathway; N.D., not determined.