TABLE 1
Summary of biexponential fits to macroscopic kinetics of desensitization and deactivation
Mutations at γ2Arg43, γ2Glu178, and β2Arg117 alter the kinetics of responses from outside-out patches to brief (2–5-ms) and longer (500-ms) pulses of 10 mM GABA. Each mutation either enhanced desensitization, slowed deactivation, or both relative to α1β2γ2 receptors. The kinetics of α1β2 receptors are listed for comparison. Data are mean ± S.E.M. Differences from α1β2γ2 were evaluated by one-way ANOVA with post hoc Dunnett’s test.