Common statistically significant (p < 0.05) alterations in the up- and down-regulation of genes after incubating MCF-7 cells for 24 h at 37°C with 311 (25 μM) or DFO (250 μM).
| Affymetrix ID | Gene Title | Gene Symbol | Gene Array (log2) | RT-PCR (log2) | ||
|---|---|---|---|---|---|---|
| 311 | DFO | 311 | DFO | |||
| Up-regulated genes | ||||||
| 201170_s_at | Basic helix-loop-helix domain containing, class B, 2 | BHLHB2 | 4.01 | 3.82 | 2.89 | 2.08 |
| 201848_s_at | BCL2/adenovirus E1B 19-kDa interacting protein 3 | BNIP3 | 3.38 | 3.33 | 3.31 | 3.82 |
| 221479_s_at | BCL2/adenovirus E1B 19-kDa interacting protein 3-like | BNIP3L | 3.48 | 3.55 | 3.48 | 2.87 |
| 207980_s_at | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | CITED2 | 3.63 | 3.65 | 4.13 | 2.90 |
| 220942_x_at | Growth and transformation-dependent protein | E2IG5 | 2.43 | 2.35 | 1.18 | 1.75 |
| 227404_s_at | Early growth response 1 | EGR1 | 4.07 | 3.88 | 1.08 | 1.21 |
| 222646_s_at | ERO1-like (S. cerevisiae) | ERO1L | 2.29 | 2.22 | 3.72 | 6.14 |
| 224657_at | ERBB receptor feedback inhibitor 1 | ERRFI1 | 2.93 | 3.25 | 0.79 | 0.49 |
| 221577_x_at | Growth differentiation factor 15 | GDF15 | 2.78 | 2.87 | 1.25 | 2.38 |
| 218507_at | Hypoxia-inducible protein 2 | HIG2 | 3.42 | 3.21 | 0.43 | 0.64 |
| 212689_s_at | Jumonji domain containing 1A | JMJD1A | 3.31 | 3.40 | 0.99 | 0.23 |
| 224602_at | HCV F-transactivated protein 1 | LOC401152 | 1.99 | 2.17 | 2.73 | 1.46 |
| 200632_s_at | N-myc downstream regulated gene 1 | NDRG-1 | 3.73 | 3.90 | 2.00 | 3.17 |
| 209034_at | Proline-rich nuclear receptor coactivator 1 | PNRC1 | 3.37 | 3.41 | 1.73 | 1.53 |
| 204566_at | Protein phosphatase 1D magnesium-dependent, δ isoform | PPM1D | 1.50 | 1.61 | 0.44 | 0.36 |
| Down-regulated genes | ||||||
| 222013_x_at | Amyloid β (A4) precursor protein (peptidase nexin-II, Alzheimer disease) | APP | −3.72 | −4.02 | −0.98 | −0.72 |