Biological processes associated with statistically significant (p < 0.05) differentially expressed genes identified from the Affymetrix Human Genome U133 Plus 2.0 gene array after incubation of MCF-7 cells for 24 h at 37°C with 311 (25 μM) or DFO (250 μM).
| 311 | DFO | |
|---|---|---|
| % | ||
| Up-regulated genes | ||
| Unknown functions | 28 | 30 |
| Nucleic acid-binding | 16 | 17 |
| Nonreceptor serine/threonine protein kinase | 11 | 11 |
| Transcription factor | 8 | 7 |
| Other functions | 7 | 7 |
| Ribosomal protein | 5 | 7 |
| Small GTPase | 5 | 5 |
| Zinc finger transcription factor | 4 | 3 |
| Guanyl-nucleotide exchange factor | 6 | |
| Protein kinase | 4 | |
| Select regulatory molecule | 3 | |
| Signaling molecule | 3 | |
| Microtubule-binding motor protein | 4 | |
| DNA helicase | 3 | |
| Exoribonuclease | 3 | |
| Receptor | 3 | |
| Down-regulated genes | ||
| Nucleic acid-binding | 24 | 20 |
| KRAB box transcription factor | 16 | 12 |
| Zinc finger transcription factor | 11 | 12 |
| Other functions | 11 | 7 |
| Guanyl-nucleotide exchange factor | 10 | 8 |
| Transcription factor | 10 | 8 |
| Unknown functions | 6 | 9 |
| G-protein modulator | 12 | |
| Non–motor actin-binding protein | 8 | |
| Nonreceptor serine/threonine protein kinase | 9 | |
| Transferase | 7 | |