TABLE 1

Gene expression of redox cycling enzymes

Gene NameSymbolAvg IntWT:IKKβ(−/−)
GSH biosynthesis
    Glutamate-cysteine ligase, modifierGclm17262.53
    Glutamate-cysteine ligase, catalyticGclc4811.52
    Glutathione synthetaseGss2871.47
GSH redox cycling enzymes
    Glutathione reductase 1Gsr7931.41
    Glutathione peroxidase 1Gpx13462−1.03
    Glutathione peroxidase 2Gpx2391.10
    Glutathione peroxidase 3Gpx3611.06
    Glutathione peroxidase 4Gpx476351.03
    Glutathione peroxidase 5Gpx5241.12
    Glutathione peroxidase 6Gpx6281.19
    Glutathione peroxidase 7Gpx739−1.13
    Cytochrome p450, 2e1Cyp2ef231.12
  • WT, wild type.