Position in the 7TMD | Opsd_bovin 11-cis-retinal | hβ2AR Carazolol | hA2A ZM241385 | hOX1 | hOX2 | ||
---|---|---|---|---|---|---|---|
SB-674042 | Almorexant | Almorexant | EMPA | ||||
2.67 | N.A. | N.A. | WT | T111A (↓) | |||
3.32 | Ala117 | Asp113 | Q126A (↓) | Q126A (↓) | S. E. | WT | |
3.33 | Thr118 | Val114 | Leu85 | A127T (↓) | A127T (↓) | WT | T135A (↓) |
3.36 | Gly121 | Val117 | WT | WT | WT | V138A (↓) | |
ECL2b (45.51) | Asp192 | WT | D203A (↓) | WT | D211A (↓) | ||
ECL2b (45.54) | Tyr191 | W206A (↓) | W206A (↓) | W214A (↓) | W214A (↓) | ||
5.38 | Phe203 | Tyr199 | Met177 | Y215A (↓) | Y215A (↓) | Y223A (↓) | Y223A (↓) |
5.42 | Met207 | Ser203 | Asn181 | F219A (↓) | F219A (↓) | F227A (↓) | F227A (↓) |
5.47 | Phe212 | Phe208 | WT | Y224A (↓) | Y232A (↓) | Y232A (↓) | |
6.48 | Trp265 | Trp286 | Trp246 | S.E. | Y311A (↓) | Y317A (↓) | Y317A (↓) |
6.51 | Tyr268 | Phe289 | Leu249 | N.A. | N.A. | WT | I320A (↓) |
7.35 | Met288 | Tyr308 | Met270 | N.A. | N.A. | F346A (↑) | WT |
7.39 | Ala292 | Asn312 | Ile274 | H344A (↓) | H344A (↓) | H350A (↓) | H350A (↓) |
7.43 | Lys296 | Tyr316 | S.E. | Y348A (↓) | WT | Y354A (↓) |
N.A., not available (the mutation was not performed); WT, the same potency as wild type; (↓), decrease in both binding affinity and potency compared with WT; S.E., small but statistically significant decrease in binding affinity; (↑), increase in binding affinity.