TABLE 1

Summary of test compounds

Compounds 1–8 show positive responses and are presented in order of high to low potency. Compounds 9 and 10 had negative responses and contain structures similar to that of pamoic acid.

Compound NumberCompound NameStructureEC50
1Pamoic acidEmbedded Image79 nM
2Pyrantel pamoateEmbedded Image83 nM
3Oxantel pamoateEmbedded Image91 nM
4ZaprinastEmbedded Image1.0 μM
5NPPBEmbedded Image4.4 μM
6DHNAEmbedded Image45 μM
73-Hydroxy-2-naphthoic acidEmbedded Image86 μM
8Kynurenic acidEmbedded Image217 μM
9Salicylic acidEmbedded ImageNo response
10Acetylsalicylic acid (aspirin)Embedded ImageNo response