TABLE 1

Structures of compounds, relative maximal ERK activity and hydrogen bonding energy between compounds and the homology model of GPR120

The relative maximal ERK response was calculated as percentage of agonistic response elicited by 100 μM compounds with respect to the response evoked by 100 μM α-LA in GPR120-expressing cells. Values are means of at least three experiments.

CompoundStructureRelative Maximum ERK responseH-Bonding EnergyCompoundStructureRelative Maximum ERK responseH-Bonding Energy
%au%au
NCG21Embedded Image1.54−5.92NCG40Embedded Image0.62−2.73
NCG20Embedded Image1.38−4.04NCG41Embedded Image0.96−2.61
NCG22Embedded Image0.93−5.07NCG42Embedded Image0.54−2.92
NCG23Embedded Image1.20−4.10NCG43Embedded Image0.70−3.10
NCG25Embedded Image1.25−4.73NCG44Embedded Image0.64−3.10
NCG26Embedded Image1.02−4.54NCG45Embedded Image0.76−3.39
NCG27Embedded Image0.55−2.23NCG46Embedded Image1.20−5.41
NCG28Embedded Image0.80−3.66NCG48Embedded Image0.92−3.98
NCG29Embedded Image1.46−3.56NCG49Embedded Image0.75−2.61
NCG30Embedded Image1.45−5.57NCG50Embedded Image1.14−4.93
NCG31Embedded Image1.40−4.06NCG51Embedded Image1.32−4.77
NCG32Embedded Image1.03−3.86NCG52Embedded Image0.29−2.70
NCG33Embedded Image0.39−2.88NCG53Embedded Image1.27−4.56
NCG34Embedded Image1.37−5.36NCG56Embedded Image1.14−3.82
NCG35Embedded Image1.48−4.75NCG57Embedded Image1.09−4.11
NCG37Embedded Image1.48−5.37MEDICA16Embedded Image0.21−1.73
NCG38Embedded Image1.24−4.87grifolic acidEmbedded Image0.41−2.31
NCG39Embedded Image1.23−4.75α-LAEmbedded Image1.00−3.03
α-LA methyl esterEmbedded Image0.00−1.38

  • au, arbitrary units.