TABLE 4
Functional antagonism of MK-7246 in human cell-based assays
HEK-CRTH2 cAMP
Whole Blood
Platelet-Rich Plasma
Eosinophil Shape Change
Eosinophil CD11b
Basophil CD11b
DP/cAMP
TP/Aggregation
IC
50
(nM)
3.0
2.2
6.2
5.4
8692
>30,000
S.D.
1.3
1.0
2.4
3.8
5289
n
4
10
5
4
8
3