TABLE 5
Rate constants fitted to experimental data in silico by fixing the k3, j3, k4, and j4 values between data sets
| NMLTC4 | LTE4 | LTD4 | |
|---|---|---|---|
| k1 (M−1·s−1) | 1.06 × 106 | 1.06 × 104 | 8.28 × 105 |
| j1 (s−1) | 9.51 × 10−2 | 9.47 × 10−3 | 1.12 × 10−1 |
| Kd1 (nM) | 89.76 | 891.9 | 135.0 |
| k2* (M−1·s−1) | 4.33 × 105 | 7.57 × 103* | 1.06 × 106 |
| j2 (s−1) | 10−4 | 1.41 × 10−3 | 7.39 × 10−2 |
| Kd2 (nM) | 0.2 | 186.2 | 69.8 |
| k3; (M−1·s−1) | 2.72 × 107 | 2.72 × 107 | 2.72 × 107 |
| j3 (s−1) | 1.04 × 10−5 | 1.04 × 10−5 | 1.04 × 10−5 |
| Kd3 (M) | 3.82 × 10−13 | 3.82 × 10−13 | 3.82 × 10−13 |
| k4 (M−1·s−1) | 2.98 × 107 | 2.98 × 107 | 2.98 × 107 |
| j4 (s−1) | 2.83 × 10−5 | 2.83 × 10−5 | 2.83 × 10−5 |
| Kd4 (M) | 9.52 × 10−13 | 9.52 × 10−13 | 9.52 × 10−13 |
| Scale factor | 58,801.8 | 58,801.8 | 58,801.8 |