Summary of findings
The entries reflect summary of data from triplicate experiments in each case.
| Ad.AC6 vs. Control | Ad.AC6mut vs. Control | |
|---|---|---|
| Iso-stimulated cAMP | ↑ 29-fold | ↓ 59-fold |
| Fsk-stimulated cAMP | ↑ 4.5-fold | ↓ 80-fold |
| PE-induced hypertrophy | ↓ 36% | ↓ 30% |
| PE-induced cell death | ↓ 57% | ↓ 55% |
| PE-associated CARP protein | ↓ 59% | ↓ 51% |
| SR Ca2+ handling | ↑ 2.4-fold | ↑ 1.7-fold |
| PLB protein | ↓ 46% | ↓ 41% |
| Basal, P-Ser16-PLB | ↑ 7-fold | N.C. |
| Iso-stimulated, P-Thr17-PLB | ↑ 2-fold | N.C. |
| Iso-stimulated, P-23/24-TnI | ↑ 1.6-fold | ↑ 1.4-fold |
N.C., no change; Fsk, forskolin; Iso, isoproterenol.