TABLE 3

Potency (pEC50), maximum response (Emax), and α value (Emax relative to norepinephrine) of the endogenous agonists norepinephrine and epinephrine at the α1A-AR

Ca2+ ReleasecAMPECAR
Norepinephrine
    pEC508.83 ± 0.065.55 ± 0.077.49 ± 0.09
    Emax84.4 ± 1.932.8 ± 0.9159.3 ± 2.7
    α1.00 (9)1.00 (7)1.00 (8)
Epinephrine
    pEC509.32 ± 0.085.83 ± 0.087.93 ± 0.06
    Emax86.6 ± 2.331.4 ± 0.8159.9 ± 1.6
    α1.03 (9)0.96 (7)1.00 (8)