NF770 | NF776 | NF778 | |||||||
---|---|---|---|---|---|---|---|---|---|
−log IC50 (95% CI) | IC50 | Normalized IC50 | −log IC50 (95% CI) | IC50 | Normalized IC50 | −log IC50 (95% CI) | IC50 | Normalized IC50 | |
nM | nM | nM | |||||||
wt-rP2X1 | 6.03 (6.20–5.86) | 939 | 49.4 | N.D. | N.D. | N.D. | N.D. | ||
rP2X2-X1 | 6.60 (6.76–6.44) | 251 | 13.2 | 6.40 (6.52–6.27) | 400 | 4.1 | 6.38 (6.47–6.29) | 415 | 3.0 |
wt-rP2X2 | 7.73 (7.79–7.67) | 19 | 1 | 7.01 (7.08–6.94) | 97 | 1 | 6.86 (6.92–6.79) | 140 | 1 |
wt-rP2X3 | 7.13 (7.21–7.05) | 74 | 3.9 | N.D. | N.D. | N.D.e | N.D. | ||
rP2X2-X3 | 7.65 (7.69–7.60) | 23 | 1.2 | 6.07 (6.14–5.99) | 861 | 8.9 | 6.18 (6.31–6.06) | 655 | 4.7 |
wt-P2X2/3 | 7.38 (7.44–7.33) | 41 | 2.2 | 6.96 (7.02–6.89) | 111 | 1.1 | 6.16 (6.23–6.08) | 698 | 5.0 |
wt-rP2X4 | > 5 | > 10,000 | > 5 | > 10,000 | > 5 | > 10,000 | |||
wt-rP2X7 | > 5 | > 10,000 | > 5 | > 10,000 | > 5 | > 10,000 |
95% CI, 95% confidence interval; N.D., not determined.