TABLE 3

Genes that were differentially expressed in the LNG of Cyp2g1-null/Cyp2a5-low and WT mice

RNA from 2-month-old male mice was used for microarray analysis, with use of the Affymetrix Mouse Expression Set 430A GeneChip arrays. LNGs from 10 mice were pooled for the preparation of each RNA sample, and a total of nine LNG RNA samples were analyzed (four from B6 WT, two from WT 129/Sv, and three from Cyp2g1-null/Cyp2a5-low). Genes with significantly changed expression (P < 0.05), and with change values either greater than 1.5-fold or smaller than 0.67-fold in comparisons of both Cyp2g1-null/Cyp2a5-low with B6 and Cyp2g1-null/Cyp2a5-low with 129/Sv in at least one probe set, are shown. Probe sets for which none of the three groups had averaged expression values greater than 60 (after GC-RMA normalization) were excluded.

Gene Symbol	Change		Gene Name
Gene Symbol	Cyp2g1-Null/Cyp2a5-Low:129/Sv	Cyp2g1-Null/Cyp2a5-low:B6	Gene Name
	fold
Ptgds	7.67/12.39	8.72/12.37	L-type prostaglandin D2 synthase
Abpa	7.45	1.75	Androgen binding protein, α^{^a}
Abpb	6.18	2.05	Androgen binding protein, β^{^b}
S100a10	2.70	1.68	S100 calcium binding protein A10
Sdc4	2.25	4.78	Syndecan 4
Cebpd	1.90	1.62	CCAAT/enhancer binding protein, delta
Abp1	1.71	2.01	Amiloride binding protein 1
Calml4	1.70	1.91	Calmodulin-like 4
Ramp1	1.66	1.56	Receptor activity modifying protein
Foxa1	1.62	1.69	Forkhead box A1
Thbs1	1.57	1.66	Thrombospondin 1
Abcc5	1.57	1.59	ATP binding cassette, subfamily C, member 5
Ccl28	1.54/1.69	1.68/1.52	C-C motif ligand 28
Igfbp5	1.53	1.69	Insulin-like growth factor binding protein 1
D6WSU176e	0.63	0.65	DNA segment Chr6, Wayne State Univ. 176, expressed
Pnliprp1	0.62	0.51	Pancreatic lipase-related protein 1
Dhrs	0.56	0.58	Dehydrogenase/reductase, member 7
Adh1	0.53	0.33	Alcohol dehydrogenase 1
Cyp2a5	0.02	0.03	Cytochrome P450, 2A5

↵a The probes used are common for a number of Abpa genes, including Abpa27.
↵b The probes used are common for a number of Abpb genes, including Abpbg27.