A1 | [Orthosteric ligand 1] |
A2 | [Orthosteric ligand 2] |
B1 | [Allosteric ligand 1] |
B2 | [Allosteric ligand 2] |
K1 | Association constant of A1 |
K2 | Association constant of A2 |
L | Receptor isomerization constant |
M1 | Association constant of B1 |
M2 | Association constant of B2 |
α1 | Intrinsic efficacy of A1 |
α2 | Intrinsic efficacy of A2 |
β1 | Intrinsic efficacy of B1 |
β2 | Intrinsic efficacy of B2 |
γ11 | Binding cooperativity between A1 and B1 |
γ12 | Binding cooperativity between A1 and B2 |
γ21 | Binding cooperativity between A2 and B1 |
γ22 | Binding cooperativity between A2 and B2 |
δ11 | Activation cooperativity between A1 and B1 |
δ12 | Activation cooperativity between A1 and B2 |
δ21 | Activation cooperativity between A2 and B1 |
δ22 | Activation cooperativity between A2 and B2 |