Important biological functions were significantly altered in LSK cells 6 and 12 h after TCDD treatment
A cutoff of 1.5-fold change (TCDD/vehicle) was set to identify transcripts whose expression was regulated. The top biological functions based on their Fisher's exact test p value (in brackets) are shown. The numbers in parentheses after the name of the functions are the number of transcripts in our data sets common to the Ingenuity Knowledge Base reference set.
| 6 h | 12 h | |
|---|---|---|
| Molecular and cellular functions | Cell-to-cell signaling and interaction (23) [9.52 × 10−4–3.92 × 10−2] | Antigen presentation (17) [2.11 × 10−8–4.44 × 10−2] |
| Cellular movement (9) [2.20 × 10−3–4.48 × 10−2] | Cell-to-cell signaling and interaction (16) [2.11 × 10−8–4.89 × 10−2] | |
| Antigen presentation (16) [2.51 × 10−3–3.92 × 10−2] | Cellular movement (14) [1.54 × 10−7–4.44 × 10−2] | |
| Cellular development (19) [4.54 × 10−3–4.31 × 10−2] | Cell death (10) [3.65 × 10−6–4.44 × 10−2] | |
| Cell morphology (4) [9.90 × 10−3–2.67 × 10−2] | Cell signaling (27) [9.02 × 10−6–2.48 × 10−3] | |
| Physiological system development and function | Hematological system development and function (44) [2.79 × 10−5–4.96 × 10−2] | Hematological system development and function (26) [2.11 × 10−8–4.89 × 10−2] |
| Tissue morphology (17) [2.79 × 10−5–2.67 × 10−2] | Immune cell trafficking (17) [2.11 × 10−8–4.89 × 10−2] | |
| Lymphoid tissue structure and development (10) [1.39 × 10−3–3.92 × 10−2] | Hematopoiesis (15) [2.75 × 10−7–4.44 × 10−2] | |
| Hematopoiesis (20) [2.20 × 10−3–4.48 × 10−2] | Lymphoid tissue structure and development (12) [6.22 × 10−5–2.25 × 10−2] | |
| Immune cell trafficking (23) [2.20 × 10−3–4.96 × 10−2] | Humoral immune response (3) [1.13 × 10−4–2.98 × 10−2] |