TABLE 2

Kinetic analysis of KIIIA K7A binding (k_on) and unbinding (k_off)

Fractional block at saturating toxin concentrations (Fb_sc) are determined from the dose-response curves in Fig. 3.

Channel	k_on	S.E.M.	k_off	S.E.M.	K_d	Fb_sc	S.E.M.
	μM⁻¹ · min⁻¹		min⁻¹		μM
Na_v1.2	0.180	0.013	0.030	0.004	0.169	0.678	0.017
Na_v1.4	0.512	0.035	0.680	0.045	1.327	0.603	0.021
Na_v1.7	0.117	0.019	0.369	0.022	3.170	0.581	0.033
Na_v1.4 Y401F	0.441	0.027	0.445	0.042	1.011	0.687	0.017
Na_v1.4 D1241I	0.455	0.056	0.603	0.046	1.326	0.625	0.029