Toxin (KIIIA) and Channel | kon | S.E.M. | koff | S.E.M. | Kd | Fbsc | S.E.M. |
---|---|---|---|---|---|---|---|
μM−1 · min−1 | min−1 | μM | |||||
R10A | |||||||
Nav1.2 | 0.140 | 0.031 | 0.022 | 0.011 | 0.158 | 0.663 | 0.030 |
Nav1.4 | 0.504 | 0.032 | 0.506 | 0.054 | 1.003 | 0.698 | 0.024 |
Nav1.7 | 0.039 | 0.007 | 0.053 | 0.019 | 1.366 | 0.521 | 0.029 |
Nav1.4 D1241I | 0.206 | 0.032 | 0.088 | 0.005 | 0.428 | 0.927 | 0.019 |
Nav1.7 I1410D | 0.015 | 0.003 | 0.039 | 0.004 | 2.545 | 0.772 | 0.033 |
H12A | |||||||
Nav1.2 | 0.129 | 0.025 | 1.392 | 0.115 | 10.791 | 0.809 | 0.021 |
Nav1.4 | 0.275 | 0.101 | 30.388 | 4.114 | 110.497 | 0.780a | 0a |
Nav1.7 | 0.106 | 0.016 | 2.035 | 0.123 | 19.282 | 0.877 | 0.019 |
a Maximal block was determined from the single-channel records in Fig. 4C.