τfast | τfast | τslow | τslow | τweighted | Remaining | n | |
---|---|---|---|---|---|---|---|
ms | % | ms | % | ms | % | ||
Deactivation after brief GABA pulses (2–4 ms, 10 mM) | |||||||
α1β2 | 26 ± 2 | 72 ± 5 | 298 ± 18 | 29 ± 5 | 103 ± 14 | N.A. | 9 |
α1β2-GKER | 22 ± 3 | 71 ± 3 | 281 ± 31 | 29 ± 3 | 96 ± 12 | N.A. | 9 |
α1β2R207A | 6 ± 1* | 90 ± 5* | 31 ± 5* | 10 ± 5* | 8 ± 1* | N.A. | 4 |
α1R67Aβ2-GKER | 4 ± 1* | 98 ± 2* | 15 ± 3* | 2 ± 2* | 4 ± 1* | N.A. | 7 |
α1R132Aβ2-GKER | 13 ± 2* | 81 ± 1 | 161 ± 31* | 19 ± 1 | 42 ± 8* | N.A. | 4 |
Desensitization during long GABA pulses (500 ms, 10 mM) | |||||||
α1β2 | 13 ± 1 | 50 ± 3 | 159 ± 14 | 20 ± 2 | 57 ± 10 | 27 ± 2 | 32 |
α1β2-GKER | 18 ± 1 | 49 ± 1 | 239 ± 30 | 23 ± 2 | 88 ± 11 | 28 ± 2 | 25 |
α1β2R207A | 11 ± 1 | 62 ± 3 | 184 ± 18 | 15 ± 2 | 42 ± 5 | 23 ± 2 | 39 |
α1R67Aβ2-GKERa | 27 ± 3* | 37 ± 4 | 217 ± 26 | 27 ± 3 | 107 ± 13 | 36 ± 3 | 15 |
α1R132Aβ2-GKER | 11 ± 1 | 62 ± 3 | 267 ± 61 | 17 ± 2 | 70 ± 15 | 21 ± 2 | 16 |
N.A., not available.
a Currents were elicited with 30 mM GABA.
*** Differences between mutants and their appropriate control (see Results) were calculated using one-way ANOVA with post-hoc Tukey test at p < 0.05 (Prism 4).