Body weight loss and organ and tumor weights in mice treated with vehicle control, Dp44mT, DpC, and gemcitabine after 44 days of treatment
Values are mean ± S.E.M. (n = 8 mice/group).
| Organ | Experimental Groups (n = 8) | |||
|---|---|---|---|---|
| Control | Dp44mT (0.4 mg/kg/day i.v.) | DpC (5 mg/kg/day i.v.) | Gemcitabine (5 mg/kg/3 days i.p.) | |
| Body weight loss, % of total weight | 104.9 ± 4.6 | 99.4 ± 5.7 | 88.0 ± 6.5*** | 104.5 ± 2.2 |
| Liver, g | 0.96 ± 0.11 | 0.88 ± 0.03 | 0.80 ± 0.03 | 1.04 ± 0.03 |
| Spleen, g | 0.12 ± 0.01 | 0.13 ± 0.01 | 0.08 ± 0.01** | 0.13 ± 0.01 |
| Kidney, g | 0.15 ± 0.02 | 0.16 ± 0.02 | 0.17 ± 0.02 | 0.19 ± 0.03 |
| Heart, g | 0.10 ± 0.01 | 0.10 ± 0.01 | 0.09 ± 0.01 | 0.10 ± 0.01 |
| Brain, g | 0.32 ± 0.02 | 0.31 ± 0.01 | 0.30 ± 0.01 | 0.32 ± 0.01 |
| Tumor, g | 0.29 ± 0.07 | 0.12 ± 0.03* | 0.04 ± 0.01*** | 0.07 ± 0.02** |
* p < 0.05.
** p < 0.01.
*** p < 0.001.