TABLE 2

Effects of 10 μM NS1643 on the time course of recovery from inactivation and of deactivation of rerg1a and rerg1a/1b channels heterologously expressed in HEK−293 cells

Data obtained from experiments as shown in Fig. 6 are given as means ± S.E.M. Tail currents were fitted with the sum of three exponential equations yielding the time constant of recovery from inactivation (τ_recovery), the time constants of fast and slow deactivation (τ_deact,fast and τ_deact,slow), and the relative contribution of the slowly deactivating current component (S/(S + F)).

	rerg1a at −110 mV (n = 5)		rerg1a/1b at −100 mV (n = 5)
	Control	NS1643	Control	NS1643
τ_recovery	1.90 ± 0.20 ms	2.94 ± 0.28 ms^*	2.87 ± 0.21 ms	4.42 ± 0.42 ms
τ_deact,fast	27.1 ± 4.9 ms	82.8 ± 11.6 ms^**	26.9 ± 2.9 ms	139.0 ± 36.28 ms^*
τ_deact,slow	278.0 ± 26.7 ms	219.4 ± 20.6 ms^*	164.9 ± 39.2 ms	461.6 ± 76.3 ms^*
S/(S + F)	11 ± 1%	34 ± 4%^*	18 ± 4%	34 ± 13%

n, number of experiments on different cells.
↵* P < 0.05.
↵** P < 0.01.
*** P < 0.001.