TABLE 1

Dose dependency of effects of NS1643 on the voltage dependence of activation and current amplitude of rerg1b channels heterologously expressed in HEK-293 cells

Data obtained from experiments as shown in Fig. 1 are given as means ± S.E.M.

NS1643 Concentration	ΔV_0.5	Increase of Maximal Outward Current	Increase of Tail Current Amplitude
0.1 μM	−6.3 ± 3.0 mV	16 ± 10%	33 ± 23%
	(n = 5)	(n = 5)	(n = 5)
1 μM	−10.5 ± 2.3 mV	52 ± 11%	34 ± 11%
	(n = 6)^**	(n = 4)^*	(n = 6)^*
10 μM	−33.4 ± 4.5 mV	304 ± 77%	283 ± 90%
	(n = 10)^***	(n = 7)^**	(n = 10)^*
30 μM	−62.0 ± 10.0 mV	121 ± 61%	185 ± 20%
	(n = 4)^*	(n = 4)^*	(n = 4)^*

ΔV_0.5, shift in the potential for half-maximal current activation; n, number of experiments on different cells.
↵* P < 0.05.
↵** P < 0.01.
↵*** P < 0.001.