TABLE 3 The effect of the α5 subunit on receptor desensitization
The receptors were activated by 1 mM ACh or 100 μM nicotine. The desensitization time courses were examined with respect to 100 to 50% of peak (or 80% for nicotine) decay time and the residual current levels at the end of the 30-s application. The data are mean ± S.D. from five to eight cells. All estimates are from traces started within 30 s of entering the whole-cell configuration. The statistical analysis applies to comparison with the data from the α3β4 and α3β4α5 receptors.