TABLE 1

Summary of the K_I, k_inact, and partition ratios for the mechanism-based inactivation of CYP2B6 WT and C475S

Details for the measurements of the kinetic parameters and partition ratios are under Materials and Methods. The reported data were averaged from four separate experiments.

CYP2B6	Clopidogrel				2-Oxo-clopidogrel
CYP2B6	K_I	k_inact	k_inact/K_I	Part. Ratio	K_I	k_inact	k_inact/K_I	Part. Ratio
	μM	min⁻¹			μM	min⁻¹
WT	2.4 ± 0.33	0.17 ± 0.031	0.071	19 ± 4	6.3 ± 0.72	0.092 ± 0.015	0.015	51 ± 8
C475S	4.2 ± 0.21	0.12 ± 0.015	0.029	17 ± 2	N.D.

N.D., not determined because of lack of inactivation.