TABLE 1

Kinetic analysis of the activity of human hexokinase isoforms HK I, HK II, and HK III, in the presence and absence of 20 μM MK-0941

The data are means ± S.E. from three separate experiments.

	V_max		K_m for Glucose
	20 μM MK-0941	Vehicle Alone	20 μM MK-0941	Vehicle Alone
	nmol · μg⁻¹ · min⁻¹		mM
HK I	4.14 ± 0.07	4.44 ± 0.11	0.038 ± 0.009	0.039 ± 0.010
HK II	9.73 ± 0.39	9.92 ± 0.58	0.103 ± 0.004	0.101 ± 0.001
HK III	8.19 ± 0.07	7.83 ± 0.10	0.018 ± 0.001	0.017 ± 0.001