TABLE 2 Distribution of compound 1 and Pmx polyglutamates in R1–11-PCFT4 and HepG2 cells
Cells were incubated for 16 h with 1 μM [3H]compound 1 or [3H]Pmx. Drug accumulations and HPLC analysis of [3H]polyglutamate metabolites were performed as described under Materials and Methods.