Effect of treatment with formoterol and salmeterol on corticosteroid sensitivity
The IC50 values of dexamethasone are shown. Values in square brackets are Dex-IC50 without treatment/Dex-IC50 with LABAs.
| No. Patients Studied | Nontreated | Formoterol (1 nM) | Salmeterol (100 nM) | |
|---|---|---|---|---|
| nM | nM | nM | ||
| Healthy | 7 | 15.5 ± 4.2 | 21.5 ± 4.8 | 31.0 ± 8.3 |
| [0.72] | [0.5] | |||
| Mild asthma | 6 | 20.0 ± 3.8 | N.D. | 14.7 ± 3.5 |
| [1.4] | ||||
| Severe asthma | 6 | 182.5 ± 28.2 | 42.8 ± 21.0 | N.D. |
| [4.3] | ||||
| 15 | 180.7 ± 28.27 | N.D. | 83.7 ± 16.7 | |
| [2.2] |
N.D., not determined.