HFD/STZ, Vehicle (n = 12) | HFD/STZ, MK-0941 (n = 12) | Lean (n = 6) | |
---|---|---|---|
Liver | |||
Weight, g | 2.3 ± 0.095 | 2.4 ± 0.14 | 1.9 ± 0.053 |
TG, mg/g | 105 ± 13 | 112 ± 18 | 13 ± 2.2* |
TC, mg/g | 7.4 ± 1.1 | 6.4 ± 1.1 | 2.7 ± 0.10* |
Plasma | |||
FFA, Eq/l | 363 ± 26 | 386 ± 37 | 187 ± 32* |
TG, mg/dl | 110 ± 12 | 83 ± 10 | 89 ± 16 |
TC, mg/dl | 215 ± 20 | 285 ± 14* | 118 ± 11* |
ALT, IU/l | 58 ± 6.2 | 52 ± 5.8 | 37 ± 14 |
AST, IU/l | 56 ± 3.9 | 65 ± 4.3 | 46 ± 8.9 |
LDH, IU/l | 262 ± 32 | 262 ± 38 | 104 ± 13* |
Lactic acid, mg/dl | 37 ± 2.9 | 40 ± 2.3 | 28 ± 3.3 |
3-HBA, μM | 120 ± 17 | 67 ± 5.3* | 103 ± 19 |
HFD/STZ, high-fat diet/low-dose streptozotocin-treated; TG, triglycerides; TC, total cholesterol; FFA, free fatty acids; ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDH, lactate dehydrogenase.
↵* P < 0.05 compared with the HFD/STZ vehicle group.