TABLE 1

Effect of 17βE2 and DHPG in the presence and absence of antagonists on [³H]InsP formation in cultured cortical neurons

Data are the mean + S.E.M. of three to eight independent experiments.

Treatment	[³H]InsP Formation
	% control
Control	100.0 ± 9.4
DHPG (100 μM)	186.1 ± 20.7^*
17βE2 (10 nM)	138.0 ± 8.2^*
DHPG + 17βE2	175.0 ± 9.0^*
DHPG + JNJ	131.0 ± 9.9^**
DHPG + ICI	117.5 ± 4.6^*
17βE2 + JNJ	93.9 ± 8.0^**
17βE2 + ICI	104.9 ± 11.7^**
JNJ (100 nM)	116.7 ± 3.7
ICI (1 μM)	99.4 ± 2.9

JNJ, JNJ 16259685; ICI, fulvestrant.
↵* P < 0.05 versus control.
↵** P < 0.05 versus respective treatment in the absence of the antagonist.