Enantiomeric effects of CM-TPMF and B-TPMF at hKCa channels in whole-cell experiments
| SC100 | Kd | |||
|---|---|---|---|---|
| (−)-CM-TPMF | (+)-CM-TPMF | (−)-B-TPMF | (+)-B-TPMF | |
| μM (n) | ||||
| hKCa2.1 | 0.0053 ± 0.00021 (6) | 0.19 ± 0.044 (5) | 0.015 ± 0.0067 (5) | 1.6 ± 0.54 (5) |
| hKCa2.2 | 0.17 ± 0.05 (4) | 2.6 ± 0.50 (4) | 0.29 ± 0.039 (4) | 13 ± 3.2(4) |
| hKCa2.3 | 0.047 ± 0.0049 (6) | 1.5 ± 0.07 (4) | 0.23 ± 0.05 (4) | 10 ± 2.3 (8) |
| hKCa3.1 | 0.12 ± 0.0049 (5) | 2.1 ± 0.12 (4) | 5.2 ± 1.0 μM (6)a | 35 ± 3.5 (3) |
↵a SC100, not Kd.