TABLE 1

Agonist and modulator evoked response characteristics

The values in square brackets indicate the number of replicate oocytes for each measurement. Fits to the Hill equation for experiments with ACh + 10 μM Mor or ACh + 10 μM Oxa in all cases, except for α3L107Hβ2, which was ACh + 50 μM Oxa.

Subtype	ACh Response		Modulation Response
	ACh Response		Mor			Oxa
	EC₅₀	n_H [n]	EC₅₀	n_H	E_max [n]	EC₅₀	n_H	E_max [n]
	μM		μM			μM
α3β2	66 ± 9	0.75 ± 0.07 [5–11]	10 ± 6	1.37 ± 0.80	2.64 ± 0.29 [5]	9 ± 1	1.54 ± 0.25	2.27 ± 0.06 [3]
α4β2	21 ± 4	0.59 ± 0.06 [6–12]	41 ± 9	0.49 ± 0.06	1.06 ± 0.14 [3–10]	370 ± 65	1.15 ± 0.36	0.85 ± 0.13 [5]
α3W53Aβ2	42 ± 2	1.08 ± 0.06 [6–10]	20 ± 3	1.28 ± 0.25	1.12 ± 0.04 [4]	47 ± 7	1.54 ± 0.24	1.16 ± 0.04 [4]
α3β2W149A	40 ± 6	0.99 ± 0.12 [5]	44 ± 6	1.38 ± 0.19	0.86 ± 0.03 [5]	110 ± 3	1.44 ± 0.06	0.90 ± 0.01 [6]
α3K109Fβ2	86 ± 14	0.66 ± 0.07 [12]	7 ± 2	1.13 ± 0.25	4.55 ± 0.22 [7]	13 ± 3	1.45 ± 0.46	3.53 ± 0.19 [5]
α3L107Cβ2	62 ± 7	0.71 ± 0.06 [6–9]	4.9 ± 0.9	1.33 ± 0.33	3.49 ± 0.15 [3]	13 ± 2	1.11 ± 0.13	1.56 ± 0.04 [7]
α3L107Hβ2	27 ± 4	1.02 ± 0.13 [17]	18 ± 2	1.15 ± 0.13	1.15 ± 0.03 [9]	106 ± 9	2.21 ± 0.78	1.04 ± 0.04 [8]
α3E113Rβ2	40 ± 5	1.01 ± 0.12 [10]	10 ± 6	1.53 ± 0.95	2.03 ± 0.22 [5]	80 ± 8	1.59 ± 0.24	0.97 ± 0.03 [5]
α3T115Cβ2	120 ± 20	0.71 ± 0.07 [9]	5 ± 2	1.48 ± 0.79	2.84 ± 0.22 [5]	9 ± 2	0.96 ± 0.21	1.62 ± 0.08 [4]
α3T115Qβ2	280 ± 40	0.96 ± 0.12 [5–10]	2.2 ± 0.6	1.27 ± 0.49	5.14 ± 0.29 [5]	18 ± 3	2.23 ± 0.75	5.03 ± 0.23 [5]
α3I117Tβ2	16 ± 2	0.93 ± 0.08 [15]	37 ± 12	0.85 ± 0.19	0.97 ± 0.07 [8]	50 ± 7	1.24 ± 0.17	0.95 ± 0.03 [7]
α3I57Eβ2	110 ± 10	0.83 ± 0.05 [5–13]	6 ± 3	0.57 ± 0.23	1.70 ± 0.17 [7]	6 ± 2	0.90 ± 0.25	1.15 ± 0.06 [6]
α3/α4[3]β2	22 ± 4	0.93 ± 0.13 [9]	26 ± 8	1.06 ± 0.32	0.94 ± 0.07 [4]	59 ± 18	1.50 ± 0.53	0.47 ± 0.04 [5]
α3/α4[5]β2	20 ± 3	1.15 ± 0.19 [10]	18 ± 5	1.31 ± 0.43	0.93 ± 0.05 [4]	94 ± 13	0.95 ± 0.11	0.88 ± 0.03 [6]