TABLE 1

Activation and inactivation gating parameters of Na_v1.4 channels in the absence or presence of metaflumizone

Values calculated from fits of data obtained in the absence or presence of 10 μM metaflumizone (Fig. 2) to the Boltzmann equation.

Condition	Activation			Fast Inactivation			Slow Inactivation
Condition	V_1/2	k	n	V_1/2	k	n	V_1/2	k	n
	mV			mV			mV
Control	−24.9 ± 0.7	5.9 ± 0.6	5	−53.3 ± 0.2	5.0 ± 0.2	5	−44.9 ± 0.7	9.3 ± 0.6	6
Metaflumizone	−20.2 ± 0.7^*	6.4 ± 0.6	5	−53.5 ± 0.2	5.2 ± 0.2	5	−48.4 ± 0.9^†	7.5 ± 0.8^†	5

V_1/2, midpoint potential for voltage-dependent activation or inactivation; k, slope factor.
↵* Significantly different from control (paired t test, P < 0.05).
↵† Significantly different from control (unpaired t test, P < 0.05).