TABLE 1

Calcium release of HEK cells expressing GIPR or GLP-1R or coexpressing GLP-1R with another glucagon receptor

The EC50 and Hill slope values from independent experiments were averaged and compared for each condition, with GIPR (GIP, n = 4; GLP-1, n = 4), GLP-1R (GIP, n = 4; GLP-1, n = 5), GLP-1R plus GIPR (GIP, n = 4; GLP-1, n = 4), GLP-1R plus GlucR (GLP-1, n = 3), and GLP-1R plus GLP-2R (GLP-1, n = 3).

GLP-1GIP
EC50Hill SlopeEC50Hill Slope
nMnM
GIPR5.0 ± 1.20.59 ± 0.27
GLP-1R41.2 ± 11.01.17 ± 0.17
GLP-1R + GIPR5.0 ± 2.60.50 ± 0.192.35 ± 0.50.63 ± 0.24
GLP-1R + GlucR26.2 ± 10.61.14 ± 0.22
GLP-1R + GLP-2R17.0 ± 2.31.02 ± 0.16