Binding affinity of the most active indenoquinoxaline derivatives and JNK inhibitor SP600125 toward selected kinases
Kd values were determined by KINOMEscan.
| Compound | Kd | |||||
|---|---|---|---|---|---|---|
| JNK1 | JNK2 | JNK3 | CK1δ | PI3Kγ | MKNK2 | |
| μM | ||||||
| IQ-1 | 0.24 | 0.36 | 0.10 | 0.38 | 0.47 | 0.92 |
| IQ-1S | 0.39 | 0.36 | 0.087 | 1.4 | 1.2 | 1.8 |
| IQ-2 | 0.33 | 0.48 | 0.09 | 0.66 | 0.58 | 1.2 |
| IQ-3 | 0.24 | 0.29 | 0.066 | 0.56 | 0.43 | 1.2 |
| IQ-4 | 0.44 | 0.58 | 0.12 | 0.66 | 0.76 | 1.8 |
| IQ-6 | 0.27 | 0.28 | 0.064 | 5.7 | 12.0 | 40.0 |
| SP600125a | 0.10 | 0.084 | 0.022 | 1.0 | ||
↵a Kd determined on same platform published previously (Fabian et al., 2005).