TABLE 1

Effects of LEV and UCB L060 (1-h pretreatment) on biophysical properties of whole-cell Ca2+ currents in SCGNs

Vehicle (n = 21)LEVUCB L060 (n = 17)
1 h (n = 17)3 h (n = 9)
Current density (measured at +10 mV), pA/pF44.3 ± 5.623.4 ± 5.5**†20.1 ± 5.1*†39.7 ± 4.8
Maximal conductance, nS30.6 ± 4.017.5 ± 4.1*††15.3 ± 3.5**†33.4 ± 4.7
Half-activation potential, mV−2.2 ± 0.7−4.3 ± 1.4−3.6 ± 1.5−5.2 ± 1.2*
Slope factor, mV4.5 ± 0.24.1 ± 0.24.2 ± 0.73.7 ± 0.3*
Reversal potential, mV58.0 ± 1.055.9 ± 1.354.1 ± 2.654.1 ± 1.2*

  • ↵* P < 0.05 versus vehicle.

  • ↵** P < 0.01 versus vehicle.

  • ↵† P < 0.05 versus UCB L060 (Mann-Whitney U test).

  • ↵†† P < 0.01 versus UCB L060 (Mann-Whitney U test).