TABLE 2

Combination index and dose reduction index values for KML001/taxane combinations

Cell Lines and Fraction Affected	KML001 Plus Paclitaxel			KML001 Plus Docetaxel
Cell Lines and Fraction Affected	CI	DRI for KML001	DRI for Paclitaxel	CI	DRI for KML001	DRI for Docetaxel
DU145
0.50	0.835	2.328	2.466	0.805	1.375	12.791
0.75	0.681	2.432	3.699	0.922	1.186	12.732
0.90	0.574	2.541	5.550	1.056	1.023	12.673
DU145/Pac200
0.50	0.470	6.529	3.156	0.792	1.514	7.637
0.75	0.407	6.674	3.892	0.859	1.370	7.736
0.90	0.355	6.821	4.800	0.934	1.240	7.837
DU145/Doc60
0.50	1.106	0.985	11.008	0.954	1.116	17.219
0.75	0.877	1.303	9.148	0.766	1.389	21.722
0.90	0.711	1.724	7.602	0.615	1.728	27.403
LNCaP
0.50	0.559	1.944	22.549	0.341	3.184	37.737
0.75	0.684	1.561	23.199	0.337	3.214	38.352
0.90	0.839	1.255	23.868	0.334	3.243	38.976
LNCaP/C81
0.50	1.640	2.574	0.799	0.403	7.329	3.745
0.75	0.790	3.242	2.079	0.603	3.966	2.846
0.90	0.430	4.084	5.407	0.928	2.146	2.163