Up-regulated genes of oxidative stress/antioxidant defense pathways in Nrf2 KO heart
| Gene Symbol | Fold Change | Function | Oxidative Stress Pathway |
|---|---|---|---|
| Scd1 | 8.1 | Stearoyl-CoA desturase-1; fatty acid and cholesterol metabolism, insulin resistance, oxidative stress | Superoxide production |
| Txnip | 4.2 | Thioredoxin-interacting protein; energy metabolism, ROS metabolism, insulin resistance, β-cell function | Inhibiting reduced thioredoxin |
| Ccs | 2.6 | Copper chaperone for superoxide dismutase; controls copper incorporation into SOD1 | Copper chaperone for SOD1 |
| Hbq1 | 2.5 | Hemoglobin subunit theta 1; early erythroid function | Oxygen transport |
| Noxa1 | 2.3 | NADPH oxidase activator 1; regulates superoxide anion production and redox signaling through NOX | NOX activator |
| Vim | 1.9 | Vimentin; cell attachment, migration, and signaling | Oxygen transport |
NOX, NADPH oxidase.