ABCA2 | ABC2 | Drug transport | Estramustine, mitoxantrone |
ABCA3 | ABC3 | Surfactant lipid transporter, lysosomal drug sequestration (Chapuy et al., 2008) | Doxorubicin, daunorubicin (Steinbach et al., 2006), imatinib (Chapuy et al., 2009) |
ABCB1 | P-gp/MDR1 | Drug transport | Multiple, including Vinca alkaloids, anthracyclines, etoposide, taxanes, imatinib, irinotecan, methotrexate, mitoxantrone |
ABCB4 | PGY3/MDR3 | Phosphatidylcholine and drug transport, bile acid secretion | Vinblastine (Wang et al., 2008), doxorubicin (Turton et al., 2001) |
ABCB5 | ABC19 | Drug transport | 5-Fluorouracil (Wilson et al., 2011), doxorubicin (Frank et al., 2005) |
ABCB11 | SPGP | Bile salt and drug transport | Paclitaxel |
ABCC1 | MRP1 | Drug transport | Multiple, including Vinca alkaloids, anthracyclines, etoposide, imatinib, irinotecan, methotrexate, mitoxantrone |
ABCC2 | MRP2 | Organic anion efflux, drug transport | Multiple, including Vinca alkaloids, anthracyclines, etoposide, taxanes, irinotecan, cisplatin, methotrexate, mitoxantrone |
ABCC3 | MRP3 | Drug transport | Etoposide |
ABCC4 | MRP4 | Nucleoside and drug transport | Irinotecan, thiopurines, methotrexate |
ABCC5 | MRP5 | Nucleoside and drug transport | Thiopurines, cisplatin, methotrexate |
ABCC6 | MRP6 | Drug transport | Anthracyclines, etoposide, cisplatin, gemcitabine (Ikeda et al., 2011) |
ABCC10 | MRP7 | Drug transport | Vinca alkaloids, taxanes |
ABCC11 | MRP8 | Drug transport | 5-Fluorouracil |
ABCC12 | MRP9 | Drug transport | None identified |
ABCG2 | ABCP/BCRP1 | Toxin efflux, drug transport | Multiple, including anthracyclines, etoposide, imatinib, flavopiridol, irinotecan, methotrexate, mitoxantrone |
LRP | LRP | Major vault transporter protein (Scheffer et al., 1995) | AML induction chemotherapy (List et al., 1996; Huh et al., 2006) |