TABLE 3
ADP modifications not compatible with agonistic activity at the WT human P2Y12
| Backbone | Position | Side Chain |
|---|---|---|
 | R1 | OH |
| R2 | H | |
| R3 | H | |
| CH3 | ||
| I | ||
| Br | ||
| R4 | NH2 | |
| R5 | CH3 | |
| R6 | Br |
The table summarizes the modifications at the ADP backbone that are not compatible with agonistic activity at the WT human P2Y12 at in least two different adenine nucleotides of the compound library (see Materials and Methods).