Genes differentially expressed between UAB30 and controls [false discovery rate (FDR) < 0.25]
For selected genes upregulated on UAB30 relative to controls, a fold change (FC) is shown for each treatment group relative to the control group. These are the fold changes for the exon of that gene with the smallest permutation P value when an empirical Bayes overall F-test is applied. The corresponding unadjusted and FDR-adjusted permutation P values are shown. Note: Two other genes that satisfied the criteria for increased expression by UAB30 and whose homologs were targets of AHR in Homo sapiens were Per1 and Bhlhe40.
| Description | Symbol | FC MeUAB030 Control | FC Targretin Control | FC UAB030 Control | Permutation P Value | FDR-Adjusted P value |
|---|---|---|---|---|---|---|
| Up: UAB | Cyp1a1 α | 1.22 | 1.97 | 54.57 | 0.00E+00 | 0.00E+00 |
| Up: UAB Dn: 4Me | Cyp1a2 α | −1.76 | −1.10 | 2.13 | 0.00E+00 | 0.00E+00 |
| Up: UAB | Cyp1b1 α | 1.19 | 1.17 | 3.04 | 1.15E-05 | 5.82E-03 |
| Up: All | Cyp2b1 γ | 3.46 | 11.33 | 4.13 | 2.70E-05 | 1.01E-02 |
| Up: 4Me and UAB | Egr1 δ,β | 2.80 | −1.06 | 2.99 | 1.70E-07 | 3.38E-04 |
| Up: All | Gsta5 δ | 2.28 | 2.92 | 2.75 | 1.23E-05 | 6.06E-03 |
| Up: UAB Dn: 4Me | Gstm3 | −1.61 | 1.10 | 1.29 | 1.75E-04 | 3.46E-02 |
| Up: 4Me & UAB | Gstp1,β | 1.86 | 1.05 | 1.37 | 1.71E-01 | 6.93E-01 |
| Up: 4Me & UAB | Nqo1 α,β | 2.64 | 1.08 | 2.23 | 1.70E-07 | 3.38E-04 |
| Up: UAB Dn: 4Me | Ugt1a6 α,β,δ | −1.83 | 1.35 | 3.21 | 5.68E-08 | 1.47E-04 |
| Up: Trg & UAB | Zbtb16 α,δ, | 1.01 | 2.40 | 4.32 | 6.23E-05 |
α Mediated by Ah receptor.
β Mediated by NRF2.
γ Mediated by CAR.
δ Mediated by HNF1α.