TABLE 4

Parameters of agonism (Emax and pEC50) for NE in the increase of intracellular Ca2+ in HEK-293 cells expressing α1A-ARs treated with vehicle, 10 µM NE/5 minutes, or 10 µM OXY/5 minutes

One-way analysis of variance followed by Dunnett’s test indicates differences from the respective value determined in cells treated with vehicle.

Treatment
Vehicle10 µM NE/5 min10 µM OXY/5 min
NE (n = 6)Emax (% of 10 µM NE)104 ± 4114 ± 635 ± 7***
pEC508.09 ± 0.118.11 ± 0.166.44 ± 0.17***

  • HEK, human embryonic kidney; NE, norepinephrine; OXY, oxymetazoline.

  • ↵*** P < 0.001.