TABLE 1

Parent ions and retention times observed for the mixed disulfide conjugates of clopidogrel in liquid chromatography tandem mass spectrometry analysis

Thiol CompoundsAbbreviationMH+ (m/z)RTa (min)MH+ Theoreticalb (m/z)
GlutathioneGSH661.055.47661.02
l-cysteineCYS475.05c5.60c475.06
l-cysteine-l-glyceineCG532.095.44532.10
γ-l-glutamyl-l-cysteineGC604.095.71604.12
CysteamineCYA431.056.33431.09
β-mercaptoethanolBME432.069.65432.07
N-acetyl-l-cysteineNAC517.116.85517.09
6-chloropyridazine-3-thiolCPT499.9911.97500.03
2,5-dimethylfuran-3-thiolDFT482.0815.80482.09
3-nitropyridine-2-thiolNPT510.0812.82510.06

  • MH+, parent ions; RT, retention times.

  • ↵a Retention time for the most intense peak.

  • ↵b Exact masses calculated from molecular formula.

  • ↵c Data from Zhang et al. (2012).