TABLE 1

CIQ does not interact with site II modulators

Mg²⁺ and ketamine concentration-response curves were measured at GluN1/GluN2D receptors expressed in oocytes and recorded using two-electrode voltage-clamp in the absence (control) or presence of CIQ (10 μM). Receptors were activated by 100 μM glutamate and 30 μM glycine at −80 mV. Mg²⁺ data are from 10 oocytes for controls and 7 oocytes for CIQ, whereas ketamine data are from 6 oocytes for both controls and CIQ. The log IC₅₀ values were not significantly different between control and CIQ for both Mg²⁺ and ketamine (P > 0.05, unpaired t test).