TABLE 1

Inhibition of ATX-mediated hydrolysis of different LPC species

ATX inhibition by the selected compounds was assessed via Amplex Red choline release assay. Fluorescence was read initially and after 2-hour incubation at 37°C at Ex/Em λ of 560/590 nm. Data (relative fluorescence) were then recorded as a mean value of the triplicates for each sample and reported as % inhibition of ATX-mediated LPC hydrolysis.