TABLE 4

Agonist transduction coefficients [log₁₀(τ/K_A)], normalized transduction coefficients [Δlog₁₀(τ/K_A)], and bias factors [ΔΔlog₁₀(τ/K_A)] for [Ca²⁺]_i mobilization and ERK1/2 phosphorylation at the M₁ mAChR

	[Ca²⁺]_i Mobilization		ERK1/2 Phosphorylation		Log Bias Factor^{^a} [Ca²⁺]_i − ERK1/2
	Log₁₀(τ/K_A)	ΔLog₁₀(τ/K_A)	Log₁₀(τ/K_A)	ΔLog₁₀(τ/K_A)	ΔΔLog₁₀(τ/K_A)
ACh	8.97 ± 0.04	0.00 ± 0.05	7.84 ± 0.03	0.00 ± 0.04	0.00 ± 0.07 (1.00)
TBPB	8.37 ± 0.04	−0.61 ± 0.06	7.09 ± 0.03	−0.73 ± 0.04	0.12 ± 0.07 (1.30)
VCP794	7.88 ± 0.06	−1.09 ± 0.07	7.59 ± 0.03	−0.22 ± 0.04	−0.87 ± 0.09 (0.14)^*

↵^a Antilogarithm of the bias factor shown in parentheses.
↵* P < 0.01, one-way analysis of variance, compared with ACh and TBPB.